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Showing posts from July, 2018

BUM: Auxin inhibitor or Footballer?

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It's the time of the Football World Cup and we are going to find out the new champion within a week or so. It was a quite exciting month, but it doesn't mean that I can take a break from my regular study/work. These days I was working on auxin inhibitors and found something really interesting to share. Here it goes. 
Auxin uses diffusion and transport system for cell to cell movement. Popular auxin transporters are AUX1 as influx carrier; PINs as efflux carrier and several ABC transporters (ABCB1 and ABCB19). We often use chemical inhibitors of transporters to understand the transport mechanism and physiological perspective of plant development. Dissect the auxin efflux by separating the involvements of PINs and ABC transporters are usually carried out through specific inhibitors targeting ABC transporters. One of them such inhibitors is 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid a.k.a. BUM. BUM does not affect PINs as like as another inhibitor Gravacin. An interesting f…